Isaac Guerendo is poised to take on a larger role in the 49ers' backfield following Jordan Mason's trade.

Guerendo presents a strategic late-round option as he sits behind McCaffrey, particularly due to McCaffrey's injury history.

Isaac Guerendo has shown promise as a capable lead back for the 49ers amidst a tumultuous injury landscape. His late-season performances evidenced his potential to handle significant touches, making him a strategic buy for fantasy teams.

Isaac Guerendo presents an intriguing buy opportunity due to his pass-catching ability, which could lead to valuable fantasy points if he can secure a leading role in San Francisco's offense.

Isaac Guerendo had a promising season for the 49ers, stepping up during injuries to key players. However, he suffered a knee injury in Week 18, initially raising concerns about a potential ACL tear. Fortunately, he confirmed that his ACL is intact, but he is likely dealing with an MCL sprain. Guerendo is expected to recover and be ready for the next season, indicating his potential to contribute further to the team.